Affiliation:
1. Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu
Abstract
IntroductionThe aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF).Material and methodsThe patient’s left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detect staining to assess histological fibrosis and ferroptosis changes.ResultsThere is a certain correlation between the degree of tissue fibrosis and ferroptosis in AF (r = 0.7763, p = 0.0004). The key proteins related to the regulation of ferroptosis were significantly abnormal in the AF group.ConclusionsFerroptosis is involved in myocardial fibrosis of AF and is a potential target for the diagnosis, prevention and treatment of AF.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献