Tetrahydrocarbazoles as potential therapeutic agents: A review of their synthesis and biological activities

Abstract

Tetrahydrocarbazoles (THCs) are a remarkable class of compounds characterized by a privileged structural scaffold centered around the natural indole moiety. This extraordinary framework appears in a multitude of naturally occurring pharmacological compounds and alkaloids, demonstrating significant inhibitory activities such as antibacterial effects, protein kinase inhibition, and tumor growth suppression. Given its versatile biological properties, THC consistently the attention of the scientific community.The primary objective of this review is to create a comprehensive reference on the synthesis and biological properties of THCs. In simpler terms, we aim to provide a detailed assessment of various catalysts, including their reaction conditions , synthesis and biological activity This review targets a broad audience interested in understanding the fascinating world of tetrahydrocarbazoles and their impact on medicine and biology .