Comparison of Pre-Operative and Post-Operative Thiol-Disulfide Levels in Acute Abdomen Patients-Reference-Cited by-同舟云学术

Comparison of Pre-Operative and Post-Operative Thiol-Disulfide Levels in Acute Abdomen Patients

Published:2023-03-22 Issue:2 Volume:13 Page:247-250
ISSN:2667-7180
Container-title:Journal of Contemporary Medicine
language:
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Author:

AYDIN Altan¹^ORCID,BULUŞ Hakan²^ORCID,YAVUZ Alper²^ORCID,TUTAN Mehmet Berksun³^ORCID,ALIŞIK Murat⁴^ORCID,EREL Özcan⁴^ORCID

Affiliation:

1. UNIVERSITY OF HEALTH SCIENCES, TRABZON KANUNİ HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF GENERAL SURGERY

2. UNIVERSITY OF HEALTH SCIENCES, ANKARA KEÇİÖREN HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF GENERAL SURGERY

3. HITIT UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF GENERAL SURGERY

4. ANKARA YILDIRIM BEYAZIT UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES (MEDICINE), DEPARTMENT OF MEDICAL BIOCHEMISTRY (MEDICINE)

Abstract

Aim: To evaluate role of thiol and disulfide homeostasis, a novel marker of oxidative stress, in the follow-up acute abdomen. Material and Method: This prospective study included 107 patients (62 men and 45 women) with a diagnosis of acute abdomen (AA). In all patients, age, gender and cause of acute abdomen were recorded. In addition, native thiol (-SH), total thiol (tSH) and disulfide (-S-S-) levels at baseline, admission and on postoperative day 3 were prospectively recorded and -SS-/-SH, -S-S-/tH and -SH/tSH ratios were calculated. Results: When the causes of acute abdomen were assessed, it was seen that 72 patients (67.29%) underwent surgery due to appendicitis while 5 patients (4.67%) due to lower GIS perforation, 7 patients (6.54%) due to perforated peptic ulcer, 5 patients (4.67%) due to sigmoid volvulus, 4 patients (3.74%) due to strangulated hernia and 14 patients (13.08%) due to miscellaneous reasons. When thiol and disulfide levels were assessed as a single parameter, mean thiol level was 316.71±78.16 (327.5) at preoperative period and 264.00±72.85 (278.30) at postoperative period. The mean thiol level was significantly decreased at postoperative period (p

Publisher

Cagdas Tip Dergisi: Journal of Contemporary Medicine

Subject

General Medicine

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