Affiliation:
1. ESKISEHIR OSMANGAZI UNIVERSITY, GRADUATE SCHOOL OF NATURAL AND APPLIED SCIENCES
2. ESKISEHIR OSMANGAZI UNIVERSITY VOCATIONAL SCHOOL OF HEALTH SERVICES
3. NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOLOJİ ANABİLİM DALI
Abstract
One of the common problems in the pathogenesis of human cancer is characterized as the dysregulation of transcription factors. SOX9 is important as it is one of the critical transcription factors involved in various diseases, including cancer. In addition, SOX9 also acts as a proto-oncogene or tumor suppressor gene, depending on the cancer type. In this study, we aimed to reveal the mutation and expression status of the SOX9 transcription factor and the effect of this gene on the survival of patients with different cancer groups. The data sets for expression analysis and overall survival analysis were performed by the GEPIA database. Analysis of the mutation profile was performed by the cBio database. As a result, SOX9 gene expressions were significantly elevated in BLCA, CESC, CHOL, COAD, ESCA, GBM, KIRP, LGG, LIHC, LUSC, OV, PAAD, READ, SKCM, STAD, TGCT, THYM, UCEC and UCS in cancer tissues compared to that in normal tissues (p
Publisher
Anadolu Universitesi Bilim ve Teknoloji Dergisi C : Yasam Bilimleri ve Biyoteknoloji