PHARMACEUTICAL DEVELOPMENT OF THROAT CANDIES WITH EXPECTORATIVE ACTION

Abstract

Introduction. Cough, especially painful paroxysmal, significantly impairs the quality of life of the patient, disrupting his sleep and reducing physical activity. Herbal expectorants with a reflex action can significantly increase the volume of bronchial secretions that young children are unable to cough up on their own, which can lead to a significant impairment of the drainage function of the lungs. A combination of herbal expectorants with secretolytics will be very effective. The creation of combination drugs that simultaneously affect various pathogenetic mechanisms of cough is a promising direction in pharmacy. Therefore, the purpose of this study is to develop the composition of lozenges with expectorant and mucolytic effects that do not cause disruption of the drainage function of the lungs. During the study, were produced 9 ready compositions of a medicine, the quality of which was assessed in accordance with the requirements of the general pharmacopoeial article of the State Pharmacopoeia of the XIV edition according to the indicators: description, disintegration, crushing strength and grateness. As a result of the analysis, it turned out that tablets containing mannitol, polyvinylpyrrolidone and magnesium stearate as excipients showed the best results and met the requirements in all respects...