Affiliation:
1. Pacific State Medical University, Vladivostok, Russian Federation
Abstract
Systemic inflammation is a complex syndrome in terms of its significance for the body. Systemic inflammation may be part of the pathogenesis of traumatic brain injury. Purpose of the study: Purpose of the study: Structural and functional characteristics of the experimental root of the left lung in systemic inflammation and traumatic brain injury. Materials and methods. To reproduce traumatic brain injury, a modified weight-drop model was used. Albino rats were studied experimental animals. To inflict injury, a device with a load (weight 200 g) was used, which falls from a height of 1 m onto the parietal region of the animal's head. For the study of experimental fever, the animals were injected intramuscularly with the pharmacopoeial form of LPS pyrogenal solution. Results. A morphological and histochemical study of the caudal lobar bronchus of the left lung of rats was carried out. The average height of the bronchial epithelium of the caudal lobar bronchus of the left lung most significantly and significantly decreases with a combination of traumatic brain injury and systemic inflammation. The bronchial epithelium retains its cilia. With the combination of SI and traumatic brain injury on the 6th day, argentophilia and an increase in the size of the nucleoli of the bronchial epithelium significantly increase. Argyrophilia of connective tissue fibers is revealed. Conclusion. With a combination of traumatic brain injury and systemic inflammation, the most informative changes in the content of mast cells are at the point of contact of the adventitial membrane of the caudal lobar bronchus of the left lung of the rat with the adventitial membrane of the caudal lobar vein of the left lung. Mastocytes localized at the site of contact between the adventitial membranes of lobe bronchus and lobe vien remain an insufficiently studied cell population of this differ on in both humans an rat. Thus, it is revealed that the pathogenesis of systemic inflammation combined with craniocerebral injury may involve dystrophically altered bronchial epithelium of the lobar bronchi, and mast cells of the adventitia of the lobar pulmonary veins.