A decade of experience in prescribing hydroxychloroquine and azithromycin: A retrospective analysis of medication queries in a Saudi drug and poison information center

Abstract

Purpose: To analyze drug information queries related to treatment with hydroxychloroquine (HCQ), chloroquine (CQ), and azithromycin submitted to a local drug and poison information center in Riyadh, Saudi Arabia. Methods: This retrospective study explored HCQ-, CQ-, and azithromycin-related inquiries submitted to the Drug and Poison Information Center at the Security Forces Hospital Program, Riyadh, Saudi Arabia. These inquiries were analyzed quantitatively and qualitatively. The quantitative analysis included the frequency of each request per year, the profession of the requesters, and the source material classification. A thematic analysis was also performed to categorize requests from healthcare professionals. Results: The Drug and Poison Information Center received 10,685 usable inquiries between 2005 and 2018. There were 160 CQ-, HCQ-, and azithromycin-related queries. Most requests were made by pharmacists (61.25 %). The main sources used to answer the queries were tertiary (92.31 %) and primary (7.69 %) sources. In the dataset, three major topics were identified: administration and dosing, safety, and pregnancy and lactation, each associated with a query subset. Conclusion: These results emphasize the importance of continued education on antimicrobial agents in general, and HCQ, CQ, and azithromycin in particular. The three items have been identified as focus areas that policymakers can us to ensure the quality of future medication prescriptions.