Study of the Biological Activity of Alkyl Derivatives of Tetrahydroisoquinolines
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Published:2021-10-21
Issue:
Volume:
Page:238-246
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ISSN:2456-9119
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Container-title:Journal of Pharmaceutical Research International
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language:
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Short-container-title:JPRI
Author:
Khamidova Umida,Terenteva Ekaterina,Umarova Mukaddas,Abdurakhmanov Jaloliddin,Sasmakov Sabirdjan,Makhnyov Artyom,Vinogradova Valentina,Saidov Abdusalom,Khashimova Zaynat,Azimova Shakhnoz
Abstract
A row of 1-alkyne (C6-C17) derivatives against tetrahydroisoquinoline have been synthesized. 1-alkyne (C6-C17) derivatives cytotoxicity against three lines of cancer cells and two lines of normal cells was studied. It was found that 1-tridecyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline exhibits a high cytotoxic effect with low toxicity to healthy cells. Antimicrobial activity of 1-alkyne (C6-C17) derivatives against 5 strains of bacteria and fungus was studied. It has been found that 1-nonyl-6,7-dimethoxy-1,3,4-tetrahydroisoquinoline exhibits strong antibacterial and antifungal effects.
Publisher
Sciencedomain International