Local drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arrays-Reference-Cited by-同舟云学术

Local drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arrays

Published:2012-07 Issue:7 Volume:3 Page:857-873
ISSN:2041-5990
Container-title:Therapeutic Delivery
language:en
Short-container-title:Therapeutic Delivery

Author:

Gulati Karan¹,Aw Moom Sinn¹,Findlay David²,Losic Dusan³

Affiliation:

1. School of Chemical Engineering, The University of Adelaide, N119 North Engineering Building, Adelaide, SA 5005, Australia

2. Discipline of Orthopaedics & Trauma, University of Adelaide, Adelaide, SA 5005, Australia

3. School of Chemical Engineering, The University of Adelaide, N119 North Engineering Building, Adelaide, SA 5005, Australia.

Abstract

Titania nanotube (TNT) arrays fabricated by electrochemical anodization of titanium are currently one of the most attractive nanomaterials due to their remarkable properties. In this review, we highlight recent research activities that are focused on the application of the TNT arrays for local drug delivery, specifically for addressing problems associated with orthopedic implants. The advantages of drug-releasing implants based on TNT arrays for local delivery of therapeutics in bone related to these challenging problems including inflammation, infection and osseointegration are discussed. An overview of recent research to advance the drug-releasing performance of TNT arrays and the potential of their future applications and development are presented.

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

Link

http://www.future-science.com/doi/pdf/10.4155/tde.12.66

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