Sensitive LC–MS/MS method for quantitation of levodopa and carbidopa in plasma: application to a pharmacokinetic study-Reference-Cited by-同舟云学术

Sensitive LC–MS/MS method for quantitation of levodopa and carbidopa in plasma: application to a pharmacokinetic study

Published:2018-10-01 Issue:19 Volume:10 Page:1567-1576
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

Ferreira Mônica S¹,Davanço Marcelo G²,Pepi Giovanni T¹,Previde Nathália¹,Gabbai José J¹,Martho Aline C¹,Brandão Amanda HY¹,Riccio Maria F¹,de Campos Daniel R²,Meulman Jessica²,Noboli Ana C¹,Júnior Pedro S¹

Affiliation:

1. Centro Avançado de Estudos e Pesquisas – CAEP, P.O. Box: 245, Campinas, SP 13087-567, Brazil

2. Medley Farmacêutica Ltda. (Sanofi Generics), Industrial Development, Campinas, SP 13080-180, Brazil

Abstract

Aim: The combination of levodopa with carbidopa has been used for treatment of Parkinson's disease being an important therapy in dopamine level control in the brain. Both are very polar compounds becoming a challenge for analysis by LC–MS/MS.Materials & methods: In this work, it was developed and validated a sensitive bioanalytical method by UHPLC–MS/MS for simultaneous levodopa and carbidopa quantification in human plasma using a fast protein precipitation method. Moreover, the bioanalytical method was applied to a pharmacokinetic study in healthy volunteers. Results/Conclusion: The results demonstrated a sensitive and adequate method for application to pharmacokinetic/bioequivalence studies.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Link

http://www.future-science.com/doi/pdf/10.4155/bio-2018-0112

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