Emerging new strategies for successful metabolite identification in metabolomics-Reference-Cited by-同舟云学术

Emerging new strategies for successful metabolite identification in metabolomics

Published:2016-03 Issue:6 Volume:8 Page:557-573
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

Bingol Kerem¹,Bruschweiler-Li Lei²,Li Dawei²,Zhang Bo³,Xie Mouzhe³,Brüschweiler Rafael²³⁴

Affiliation:

1. Pacific Northwest National Laboratory, Richland, WA 99352, USA

2. Campus Chemical Instrument Center, The Ohio State University, Columbus, OH 43210, USA

3. Department of Chemistry & Biochemistry, The Ohio State University, Columbus, OH 43210, USA

4. Department of Biological Chemistry & Pharmacology, The Ohio State University, Columbus, OH 43210, USA

Abstract

This review discusses strategies for the identification of metabolites in complex biological mixtures, as encountered in metabolomics, which have emerged in the recent past. These include NMR database-assisted approaches for the identification of commonly known metabolites as well as novel combinations of NMR and MS analysis methods for the identification of unknown metabolites. The use of certain chemical additives to the NMR tube can permit identification of metabolites with specific physical chemical properties.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Link

http://www.future-science.com/doi/pdf/10.4155/bio-2015-0004

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