PK–PD interaction study of angiotensin II antagonist, losartan, with selective estrogen receptor modulator, centchroman

Abstract

Aim: The effect on pharmacokinetics and postcoital contraceptive efficacy of centchroman was investigated after concomitant administration of losartan. Materials & methods: An LC-MS/MS method was employed for quantification of centchroman in blood of female rats treated with centchroman (1.5 mg/kg) only and centchroman plus losartan (5 mg/kg, once daily up to day 7). The effect of losartan on the postcoital contraceptive activity of centchroman was evaluated in sperm-positive female rats. Results: The area under the curve and mean residence time values were decreased in losartan concomitant group, however, sperm-positive female rats did not exhibit any implantations in either centchroman only or losartan co-administered group of female rats. Conclusion: The study evidenced no pharmacological interaction of losartan with centchroman.