Prospective single center trial of next-generation sequencing analysis in metastatic renal cell cancer: the MORE-TRIAL-Reference-Cited by-同舟云学术

Prospective single center trial of next-generation sequencing analysis in metastatic renal cell cancer: the MORE-TRIAL

Published:2018-06-01 Issue:5 Volume:4 Page:FSO299
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Dieffenbacher Svenja¹,Zschäbitz Stefanie²,Hofer Luisa¹,Hatiboglu Gencay¹,Hou Weibin³,Hohenfellner Markus¹,Duensing Stefan³,Sültmann Holger⁴,Pahernik Sascha⁵,Grüllich Carsten¹

Affiliation:

1. The Renal Cancer Center at the National Center for Tumor Diseases (NCT) Heidelberg, Germany, Department of Urology, Heidelberg University Hospital, Im Neuenheimer Feld 110, Heidelberg, Germany

2. The Renal Cancer Center at the National Center for Tumor Diseases (NCT) Heidelberg, Germany, Department of Medical Oncology, National Center for Tumor Diseases Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 460, Heidelberg, Germany

3. The Renal Cancer Center at the National Center for Tumor Diseases (NCT) Heidelberg, Germany, Section of Molecular Uro-oncology, Department of Urology, Heidelberg University Hospital, Im Neuenheimer Feld 110, Heidelberg, Germany

4. The Renal Cancer Center at the National Center for Tumor Diseases (NCT) Heidelberg, Germany, Cancer Genome Research Group, German Cancer Consortium (DKTK), Heidelberg, Germany, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT), Heidelberg, Germany

5. The Renal Cancer Center at the National Center for Tumor Diseases (NCT) Heidelberg, Germany, Department of Urology, Nuremberg General Hospital, Paracelsus Medical University, Nuremberg, Germany

Abstract

Aim: Targeted therapies have substantially improved the survival of patients with metastatic clear cell renal cell cancer. No prognostic or predictive biomarkers are available. Comprehensive genetic profiling offers the opportunity to define prognostic and predictive signatures aiming at a more personalized approach to treatment. Methods: In this prospectively conducted cohort study, tumor tissue and liquid biopsies are sampled at baseline and upon first and second progression under systemic treatment. Samples will be analyzed by whole-exome sequencing to generate prognostic and predictive patterns for systemic therapies. Discussion: This study is aiming at exploring genetic profiles with prognostic and predictive value in metastatic renal cell cancer patients. Clonal evolution facilitating resistance to systemic treatment will be investigated by repeat biopsies.

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.4155/fsoa-2017-0150

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Genomic analyses of renal cell carcinoma employing next generation sequencing;Die Onkologie;2023-06-15

2. Identification of a four immune‐related genes signature based on an immunogenomic landscape analysis of clear cell renal cell carcinoma;Journal of Cellular Physiology;2020-05-26