Laser-induced thermal ablation of cancerous cell organelles

Abstract

Aim: By exploiting the physical changes experienced by cancerous organelles, we investigate the feasibility of destroying cancerous cells by single and multipulse modes of laser heating. Materials & methods: Our procedure consists of two primary steps: determining the normal and cancerous organelles optical properties and simulating the heating of all of the major organelles in the cell to find the treatment modes for the laser ablation of cancerous organelles without harming healthy cells. Results & conclusion: Our simulations show that the cancerous nucleus can be selectively heated to damaging temperatures, making this nucleus a feasible therapeutic particle and removing the need for nanoparticle injection. Because of the removal of this extra step, the procedure we propose is simpler and safer for the patient.