The metabolism of anabolic-androgenic steroids in the greyhound-Reference-Cited by-同舟云学术

The metabolism of anabolic-androgenic steroids in the greyhound

Published:2013-04 Issue:7 Volume:5 Page:769-781
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

McKinney Andrew R¹,Cawley Adam T²,Young E Bruce³,Kerwick Carmel M³,Cunnington Karen³,Stewart Rhiannon T⁴,Ambrus Joseph I⁴,Willis Anthony C⁴,McLeod Malcolm D⁴

Affiliation:

1. Australian Racing Forensic Laboratory. Currently with the Department of the President’s Affairs, PO Box 17292, Al Ain, United Arab Emirates.

2. Australian Racing Forensic Laboratory, PO Box 528, Kensington, NSW 1465, Australia

3. Queensland Government Racing Science Centre, PO Box 513, Albion, QLD 4010, Australia

4. Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia

Abstract

Background: Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered human and veterinary AASs available in the region. Results: Canine metabolic data are presented for the AASs boldenone, danazol, ethylestrenol, mesterolone, methandriol, nandrolone and norethandrolone. The principal Phase I metabolic processes observed were the reduction of A-ring unsaturations and/or 3-ketones with either 3α,5β- or 3β,5α-stereochemistry, the oxidation of secondary 17β-hydroxyl groups and 16α-hydroxylation. The Phase II β-glucuronylation of sterol metabolites was extensive. Conclusion: The presented data have enabled the effective analysis of AASs and their metabolites in competition greyhound urine samples.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Link

http://www.future-science.com/doi/pdf/10.4155/bio.13.40

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