Natural product scaffolds as leads to drugs-Reference-Cited by-同舟云学术

Natural product scaffolds as leads to drugs

Published:2009-11 Issue:8 Volume:1 Page:1415-1427
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Newman David J¹,Cragg Gordon M¹

Affiliation:

1. Natural Products Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, MD 21702, USA.

Abstract

Numerous ‘scaffolds’ that have been identified in natural product structures have led to very significant numbers of approved drugs and drug candidates for a multiplicity of diseases over the years. In this mini-review, we discuss the base scaffolds (chemical skeletons) that we feel have produced very significant numbers of agents as drugs or drug leads and, in a number of cases, compounds that can be used as chemical synthons or that present activities in biological areas that were not obvious from their earlier history.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc.09.113

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