Biomarkers and biomeasures: key enablers for pharmacokinetic–pharmacodynamic modeling in drug discovery and development
Author:
Affiliation:
1. MedImmune, Cambridge, CB21 6GH, UK.
2. Pfizer, Sandwich CT13 9NJ, UK
Publisher
Future Science Ltd
Subject
Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry
Link
http://www.future-science.com/doi/pdf/10.4155/bio.12.88
Reference11 articles.
1. Pharmacodynamic-Pharmacokinetic Integration as a Guide to Medicinal Chemistry
2. Integration not isolation: arguing the case for quantitative and systems pharmacology in drug discovery and development
3. Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development
4. RowlandM, Towzer R.Clinical Pharmacokinetics (Fourth Edition). Lippincott, Williams & Wilkins, MD, USA,3–17 (2007).
5. Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling: Biophase Distribution, Receptor Theory, and Dynamical Systems Analysis
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