siRNA therapeutics in the treatment of diseases-Reference-Cited by-同舟云学术

siRNA therapeutics in the treatment of diseases

Published:2013-01 Issue:1 Volume:4 Page:45-57
ISSN:2041-5990
Container-title:Therapeutic Delivery
language:en
Short-container-title:Therapeutic Delivery

Author:

Bakhtiyari Salar¹,Haghani Karimeh¹,Basati Gholam²,Karimfar Mohammad Hassan³

Affiliation:

1. Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran

2. Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

3. Department of Anatomical Sciences, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran

Abstract

siRNAs are a class of dsRNAs, 21–23 nucleotides in length, which are able to silence their target genes through enzymatic cleavage of target mRNA. The sequence-specific gene-silencing by siRNA can be used as a new therapeutic approach for treatment of a variety of diseases that are incurable by conventional drugs. Many efforts have been made to overcome the problems related to delivery, stability, off-target gene silencing and immunostimulatory effects of siRNA. Different studies have carried out done to improve in vitro and in vivo delivery of naked or formulated siRNAs. In this review, different aspects of using siRNA as a new class of drugs will be discussed.

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

Link

http://www.future-science.com/doi/pdf/10.4155/tde.12.136

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