Affiliation:
1. Case Western Reserve University
2. University Hospitals Case Medical Center
3. Stanford University
Abstract
Abstract
The biocompatibility of a material relates to its immunological response, toxicity profile, and ability to integrate with surrounding tissue without undesirable local or systemic effects on a patient. This article underscores the transformation of the medical device design ecosystem engaged as an integral part of the device ecosystem. It discusses the applications of biomaterials, including orthopedic, cardiovascular, ophthalmic, and dental applications. The article describes four major categories of biomaterials such as metals, polymers, glass and ceramics, and composites. A discussion on natural materials, nanomaterials, and stem cells is also provided. The article concludes with examples of biomaterials applications, such as endovascular devices, knee implants, and neurostimulation.
Reference122 articles.
1. Definitions in Biomaterials;Williams,1986
2. On Mechanisms of Biocompatibility;Williams;Biomaterials,2008
3. “Biological Evaluation of Medical Devices,” TC-194, International Organization for Standardization, 2009, http://www.iso.org/iso/catalogue_detail.htm?csnumber=44908 (accessed Sept 2011)
4. Shattuck Lecture: Innovation, Regulation, and the FDA;Hamburg;New Engl. J. Med.,2010
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