Adverse childhood experiences and resilience among adult women: A population-based study

Author:

Daníelsdóttir Hilda Björk12ORCID,Aspelund Thor1ORCID,Thordardottir Edda Bjork1ORCID,Fall Katja34ORCID,Fang Fang4ORCID,Tómasson Gunnar1ORCID,Rúnarsdóttir Harpa1,Yang Qian2ORCID,Choi Karmel W56ORCID,Kennedy Beatrice7ORCID,Halldorsdottir Thorhildur18ORCID,Lu Donghao46ORCID,Song Huan9ORCID,Jakobsdóttir Jóhanna1ORCID,Hauksdóttir Arna1ORCID,Valdimarsdóttir Unnur Anna126ORCID

Affiliation:

1. Centre of Public Health Sciences, Faculty of Medicine, University of Iceland

2. Department of Medical Epidemiology & Biostatistics, Karolinska Institutet

3. Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University

4. Institute of Environmental Medicine, Karolinska Institutet

5. Department of Psychiatry, Massachusetts General Hospital

6. Harvard T.H. Chan School of Public Health

7. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University

8. Department of Psychology, Reykjavík University

9. West China Biomedical Big Data Center, West China Hospital, Sichuan University

Abstract

Background:Adverse childhood experiences (ACEs) have consistently been associated with elevated risk of multiple adverse health outcomes, yet their contribution to coping ability and psychiatric resilience in adulthood is unclear.Methods:Cross-sectional data were derived from the ongoing Stress-And-Gene-Analysis cohort, representing 30% of the Icelandic nationwide female population, 18–69 years. Participants in the current study were 26,198 women with data on 13 ACEs measured with the ACE-International Questionnaire. Self-reported coping ability was measured with the Connor-Davidson Resilience Scale and psychiatric resilience was operationalized as absence of psychiatric morbidity. Generalized linear regression assuming normal or Poisson distribution were used to assess the associations of ACEs with coping ability and psychiatric resilience controlling for multiple confounders.Results:Number of ACEs was inversely associated with adult resilience in a dose-dependent manner; every 1SD unit increase in ACE scores was associated with both lower levels of coping ability (β = −0.14; 95% CI-0.15,–0.13) and lower psychiatric resilience (β = −0.28; 95% CI-0.29,–0.27) in adulthood. Compared to women with 0 ACEs, women with ≥5 ACEs had 36% lower prevalence of high coping ability (PR = 0.64, 95% CI 0.59,0.70) and 58% lower prevalence of high psychiatric resilience (PR = 0.42; 95% CI 0.39,0.45). Specific ACEs including emotional neglect, bullying, sexual abuse and mental illness of household member were consistently associated with reduced adult resilience. We observed only slightly attenuated associations after controlling for adult socioeconomic factors and social support in adulthood.Conclusions:Cumulative ACE exposure is associated with lower adult resilience among women, independent of adult socioeconomic factors and social support, indicating that adult resilience may be largely determined in childhood.Funding:This work was supported by the European Research Council (Consolidator grant; UAV, grant number 726413), and the Icelandic Center for Research (Grant of excellence; UAV, grant number 163362-051). HBD was supported by a doctoral grant from the University of Iceland Research Fund.

Funder

Icelandic Centre for Research

H2020 European Research Council

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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