Vilya, a component of the recombination nodule, is required for meiotic double-strand break formation in Drosophila

Author:

Lake Cathleen M1,Nielsen Rachel J1,Guo Fengli1,Unruh Jay R1,Slaughter Brian D1,Hawley R Scott12

Affiliation:

1. Stowers Institute for Medical Research, Kansas City, United States

2. Department of Molecular and Integrative Physiology, Kansas University Medical Center, Kansas City, United States

Abstract

Meiotic recombination begins with the induction of programmed double-strand breaks (DSBs). In most organisms only a fraction of DSBs become crossovers. Here we report a novel meiotic gene, vilya, which encodes a protein with homology to Zip3-like proteins shown to determine DSB fate in other organisms. Vilya is required for meiotic DSB formation, perhaps as a consequence of its interaction with the DSB accessory protein Mei-P22, and localizes to those DSB sites that will mature into crossovers. In early pachytene Vilya localizes along the central region of the synaptonemal complex and to discrete foci. The accumulation of Vilya at foci is dependent on DSB formation. Immuno-electron microscopy demonstrates that Vilya is a component of recombination nodules, which mark the sites of crossover formation. Thus Vilya links the mechanism of DSB formation to either the selection of those DSBs that will become crossovers or to the actual process of crossing over.

Funder

Stowers Institute for Medical Research

American Cancer Research

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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