A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use-Reference-Cited by-同舟云学术

A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use

Published:2024-09-05 Issue: Volume:13 Page:
ISSN:2050-084X
Container-title:eLife
language:en
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Author:

Weng Yihe¹^ORCID,Kruschwitz Johann²³,Rueda-Delgado Laura M¹^ORCID,Ruddy Kathy L¹⁴^ORCID,Boyle Rory¹,Franzen Luisa¹⁵,Serin Emin²⁶⁷^ORCID,Nweze Tochukwu⁸,Hanson Jamie⁹,Smyth Alannah¹,Farnan Tom¹^ORCID,Banaschewski Tobias¹⁰,Bokde Arun LW¹¹,Desrivières Sylvane¹²,Flor Herta¹³¹⁴,Grigis Antoine¹⁵,Garavan Hugh¹⁶,Gowland Penny A¹⁷,Heinz Andreas²,Brühl Rüdiger¹⁸^ORCID,Martinot Jean-Luc¹⁹^ORCID,Martinot Marie-Laure Paillère¹⁹²⁰,Artiges Eric¹⁹²¹,McGrath Jane¹¹,Nees Frauke¹⁰¹³²²,Papadopoulos Orfanos Dimitri¹⁵^ORCID,Paus Tomas²³²⁴,Poustka Luise²⁵,Holz Nathalie¹⁰,Fröhner Juliane²⁶,Smolka Michael N²⁷^ORCID,Vaidya Nilakshi²⁸,Schumann Gunter²⁷²⁸,Walter Henrik²,Whelan Robert¹^ORCID,

Affiliation:

1. School of Psychology and Global Brain Health Institute, Trinity College Dublin

2. Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health

3. Collaborative Research Centre (SFB 940) 'Volition and Cognitive Control', Technische Universität Dresden

4. School of Psychology, Queens University Belfast

5. Faculty of Psychology and Neuroscience, Maastricht University

6. Charité – Universitätsmedizin Berlin, Einstein Center for Neurosciences Berlin

7. Bernstein Center for Computational Neuroscience

8. Department of Psychology, University of Utah

9. Department of Psychology, Learning Research & Development Center, University of Pittsburgh

10. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University

11. Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin

12. Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology, & Neuroscience, SGDP Centre, King’s College London

13. Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Heidelberg University

14. Department of Psychology, School of Social Sciences, University of Mannheim

15. NeuroSpin, CEA, Université Paris-Saclay

16. Departments of Psychiatry and Psychology, University of Vermont

17. Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park

18. Physikalisch-Technische Bundesanstalt (PTB)

19. Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 'Trajectoires développementales & psychiatrie', University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli

20. AP-HP Sorbonne University, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital

21. Psychiatry Department, EPS Barthélémy Durand

22. Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University

23. Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hosptalier Universitaire Sainte-Justine, University of Montreal

24. Departments of Psychiatry and Psychology, University of Toronto

25. Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen

26. Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden

27. Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin

28. Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University

Abstract

Substance use, including cigarettes and cannabis, is associated with poorer sustained attention in late adolescence and early adulthood. Previous studies were predominantly cross-sectional or under-powered and could not indicate if impairment in sustained attention was a predictor of substance use or a marker of the inclination to engage in such behavior. This study explored the relationship between sustained attention and substance use across a longitudinal span from ages 14 to 23 in over 1000 participants. Behaviors and brain connectivity associated with diminished sustained attention at age 14 predicted subsequent increases in cannabis and cigarette smoking, establishing sustained attention as a robust biomarker for vulnerability to substance use. Individual differences in network strength relevant to sustained attention were preserved across developmental stages and sustained attention networks generalized to participants in an external dataset. In summary, brain networks of sustained attention are robust, consistent, and able to predict aspects of later substance use.

Funder

China Scholarship Council - Trinity College Dublin Joint Scholarship Programme

European Union-funded FP6 Integrated Project IMAGEN

Horizon 2020

Medical Research Council

National Institutes of Health

Medical Research Foundation and Medical Research Council

European Union funded project 'environMENTAL'

Agence Nationale de la Recherche

Science Foundation Ireland

Publisher

eLife Sciences Publications, Ltd