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Building a better blood-brain barrier

Published:2017-10-10 Issue: Volume:6 Page:
ISSN:2050-084X
Container-title:eLife
language:en
Short-container-title:

Author:

Lane-Donovan Courtney¹^ORCID,Herz Joachim²³⁴⁵^ORCID

Affiliation:

1. Department of Neurology, University of California San Francisco, San Franciso, United States

2. Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, United States

3. Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, United States

4. Department of Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, United States

5. Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, United States

Abstract

A new three-dimensional model of the blood-brain barrier can be used to study processes that are involved in neurodegenerative diseases.

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://cdn.elifesciences.org/articles/31808/elife-31808-v1.pdf

Reference11 articles.

1. The projected effect of risk factor reduction on Alzheimer's disease prevalence;Barnes;The Lancet Neurology,2011

2. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance;Castellano;Science Translational Medicine,2011

3. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families;Corder;Science,1993

4. Engineering of arteries in vitro;Huang;Cellular and Molecular Life Sciences,2014

5. Aβ42 is essential for parenchymal and vascular amyloid deposition in mice;McGowan;Neuron,2005

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1. The apolipoprotein receptor LRP3 compromises APP levels;Alzheimer's Research & Therapy;2021-11-02

2. Fabrication of fibrillated and interconnected porous poly(ε-caprolactone) vascular tissue engineering scaffolds by microcellular foaming and polymer leaching;RSC Advances;2020

3. Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective;Trends in Biotechnology;2018-04

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