Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR
Author:
Affiliation:
1. Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge, United Kingdom
2. Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany
Abstract
Funder
Medical Research Council
European Molecular Biology Organization
Deutsche Forschungsgemeinschaft
Wellcome
Publisher
eLife Sciences Publications, Ltd
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience
Link
https://cdn.elifesciences.org/articles/50793/elife-50793-v2.pdf
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3. Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox;Avezov;The Journal of Cell Biology,2013
4. Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude;Bakunts;eLife,2017
5. BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions;Behnke;Journal of Molecular Biology,2015
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