Estimation and Validation of Abrocitinib Dosage Form and in Bulk Drug by Spectrophotometric Method-Reference-Cited by-同舟云学术

Estimation and Validation of Abrocitinib Dosage Form and in Bulk Drug by Spectrophotometric Method

Published:2023-06-28 Issue: Volume: Page:230-234
ISSN:0974-4150
Container-title:Asian Journal of Research in Chemistry
language:en
Short-container-title:AJRC

Author:

Fathima Husnain¹,Yakhoob Mohammed¹,Khaleel Mohamed¹

Affiliation:

1. Department of Pharmaceutical Chemistry, MMU College of Pharmacy, Ramanagar-562159 Karnataka, India.

Abstract

A simple, sensitive, accurate, rapid and economical Spectrophotometric method was developed for estimation and validation of Abrocitinib in pure drug and tablet dosage form. The absorbance was measured at 303.0nm using Dimethylsulfoxideas solvent system. It obeyed Beer’s law at the concentration range of 2-14µg/ml with coefficient of correlation (r2) of 0.998. Limit of detection (LOD) was found to be 1.226µg/ml and Limit of quantitation (LOQ) was found to be 5.226µg/ml. The proposed analytical method was validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness.

Publisher

A and V Publications

Subject

General Medicine

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