Affiliation:
1. Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Kalwan. Dist. Nashik (M.S.) 423501. India.
Abstract
Loratadine, a histamine H1 receptor antagonist, is used to treat urticaria and allergic rhinitis. Children who have trouble swallowing tablets make it difficult to administer loratadine orally. F1-F9 batches of Loratadine Tablets (ODTs) 10 mg dose were developed and tested in the present research. In this research, super disintegrants such as croscarmellose sodium, sodium starch glycolate, and crosspovidone were used to manufacture fast-dissolving tablets utilising the direct compression method. In phosphate buffer pH 6.8, the impact of various super disintegrants on tablet dissolving behaviour was examined.
Reference15 articles.
1. Haria M, et al. Loratadine: A reappraisal of its pharmacological properties and therapeutic use in allergic disorders. Drugs. 1994; 48: 617–37.
2. Nehal siddiqui M D, Garima G and Pramod Kumar S. A Novel Approach in Oral Fast Dissolving Drug Delivery System and Their Patents. Advances in Biological Research. 2011; 5 (6): 291-303.
3. Kuchekar B S, Atul B C, Mahajan H S. Mouth dissolving tablets: a novel drug delivery system. Pharma Times. 2003; 35: 7- 9.
4. Bhupendra G.Prajapati, Bhaskar Patel. Formulation, Evaluation and Optimization of Orally Disintegrating Tablet of Piroxicam. International Journal of PharmTech Research. 2010: 2(30); 1893- 1899.
5. Bi Y, Sunada H, Yonezawa Y, Dayo K, Otsuka A, Iida K. Preparation and evaluation of compressed tablet rapidly disintegrating in oral cavity. Chem Pharm Bull (Tokyo) 1996; 44: 2121-2127.