Fabrication and Evaluation of Polymeric Nanoparticles of Acitretin for the Solubility Enhancement

Abstract

The present study was an attempt to prepare nanoparticle of Acitretin which is used in Psoriasis. The preparation of nanoparticles was done by precipitation method employing several blends of polymers such as PVPK 30, PVPK 90, Poloxamer 407 and Poloxamer 188. The oral nanoparticles were characterized for various physicochemical parameters, such as particle size analysis, drug-excipient interactions, zeta potential, saturated solubility, XRD study, in-vitro drug release, FTIR spectroscopic studies displayed that there were not any interactions between drug and excipients. The nanoparticle batch F8 was found to be optimum batch based upon the outcomes obtained from the physicochemical characterization of nanoparticles. The mean particle size of nanoparticle batch F8 containing showed 96.01 % release at the end of 90 min and formulation displayed good nanoparticle strength.