Cardioprotective effect of Extract Ethanol Ocimum basilicum on Rat Induced Cisplatin

Abstract

Cisplatin is a potent chemotherapy drug that is associated with several side effects such as myelotoxicity, gastrointestinal toxicity, ototoxicity neurotoxicity, cardiotoxicity, and nephrotoxicity2-5. Cardiotoxic manifestations of cisplatin chemotherapy have been described: heart failure, angina, acute myocardial infarction, thromboembolic events, autonomic cardiovascular dysfunction, both hypertension and hypotension, myocarditis, pericarditis, and severe congestive cardiomyopathy. Oxidative stress that occurs when antioxidant defenses are inadequate can damage lipids, proteins, carbohydrates, and DNA. (Ocimum bacilicum) which belongs to the Lamiaceae family as a rich source of phytochemical compounds that can show countless pharmacological effects. This study aims to determine the cardioprotective activity of extract ethanol of Ociumum bacilicium on rats induced cisplatin. The result show that ethanol extract of Ocimum bacilicum has antioxidant activity. The cardioprotective activity of ethanol extract of Ocimum bacilicum by reducing the level of CK-MB and LDH as cardiac biomarker. Extract dose 300mg/kg BB reduce the level of CK-MB into 1200,427±15,924ng/mL meanwhile the level of LDH into 7,345±0,064 ng/mL. Briefly, it can be concluded that Ociumum bacilicium has cardioprotective effect.