Formulation and Development of Nanoparticulate System containing Rutin from Leaves Extract of Aegle marmelos for effective Management of Diabetes

Abstract

Current work aimed at the modified release of content from carrier system at predetermined rate and secondly, to decrease the use of synthetic drug on biological system. Successive solvent extraction of crude drug of Aegle marmelos plant was done. Active constituent of leaves that is rutin was isolated and identified through HPTLC and FTIR. SLN was selected as carrier system and fabricated by solvent diffusion method. Characterization and performance evaluation of particulate system loaded with herbal plant extract of the Aegle marmelos leaves was done. TEM, In-vitro drug release profile, entrapment efficiency and particle size was determined. Solid lipid nanoparticles have enormous effect in loading high amount or loading dose concentration in body and also maintain the same over prolonged interlude of time. SLN was formulated and characterized for the particle size, shape and its distribution, percentage drug entrapment and In-vitro drug release profile along with the stability studies. In-vivo bio distribution studies on animals suggested the accumulation of formulations in the different organs. Solid lipid nanoparticles also show good stability as compared to other novel carrier systems. Prolonged release of natural drug from carrier system, decrease the dosing frequency and also decrease the dose size. Better results than marketed synthetic anti-diabetic drugs.