Anti Cancer Potential of some Indole based Quinoxaline Derivatives against Dalton’s Lymphoma (DL) cells-Reference-Cited by-同舟云学术

Anti Cancer Potential of some Indole based Quinoxaline Derivatives against Dalton’s Lymphoma (DL) cells

Published:2023-07-24 Issue: Volume: Page:3165-3171
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Bajpai Shivam¹,Singh Sundaram²

Affiliation:

1. Department of Chemistry, Bipin Bihari College, Affiliated To Bundelkhand University, Jhansi- 284001, U.P., India.

2. Department of Chemistry, Indian Institute of Technology, Banaras Hindu University, Varanasi – 221 005, U.P., India.

Abstract

Indole based quinoxaline derivatives (2a-f) were synthesized and the therapeutic potential of the synthesized compounds (2a-f) was investigated against Dalton’s Lymphoma (DL) cells. It was observed that treatment of DL cells with quinoxaline derivatives (2a-f) showed significant decrease in cell viability, altered morphology, nuclear disintegration and DNA fragmentation into low molecular weight DNA fragments and thus characteristic of apoptosis. In this view, the synthesized compounds may be used as potential therapeutic regimen to treat this type of cancer.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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