Formulation, Evaluation and Study of Super Disintegrants effect on Olmesartan Medoxomil Fast Dissolving Tablets

Author:

Ramu Anne1,Vidyadhara Suryadevara1,Ramesh Babu Janga1,Sowjanya Lakshmi Battula1,Ramya Krishna Seelam1

Affiliation:

1. Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur - 522019.

Abstract

The current research was to enhance solubility and dissolution rate of the slightly soluble drug, Olmesartan medoxomil, solid dispersions by physical mixing, solvent evaporation and kneading techniques, with soluplus. The solid dispersions prepared are tested for flow properties, drug content, and particle size. In vitro dissolution studies were carried out to analyse the drug release from solid dispersions. Crystal morphology, drug and polymer interaction for selected solid dispersions was studied by FT-IR and DSC analysis. Fast-dissolving tablets were formulated by using optimized solid dispersions using different concentrations of sodiumstarch glycolate, crosscarmellosesodium, and crospovidone as superdisintegrants using direct compression technique. The tablets prepared are tested for Weight variation, friability, disintegration, content uniformity and harness. The mechanism and kinetics of drug release from the fast-dissolving tablets were tested by in-vitro dissolution studies. The current research proves that combining solid dispersions along with the use of superdisintegrants is novel approach to formulate of Olmesartan medoxomil fast-dissolving tablets.

Publisher

A and V Publications

Reference15 articles.

1. Punitha S. Srinivasa Reddy G. Srikrishna T. Lakshman Kumar M. Solid Dispersions: A Review. Journal of Pharmacy and Technology. 2011; 4(3): 331-334.

2. Kuldeep M. Ashok Y. Sunil K. Pankaj R. Fast Dissolving Drug Delivery System: A Review. Research Journal of Pharmacy and Technology. 2011; 4(6): 842-850.

3. Sneha DB. A Review on Solid Dispersion as a Technique for Enhancement of Bioavailability of Poorly Water Soluble Drugs. Research Journal of Pharmacy and Technology. 2014; 7(12): 96-100.

4. Sajid Ali MD. Sarfaraz A. Sarfaraz MD. Nawazish AM. Research Trend in Fast Dissolving Tablets: An Overview. Journal of Pharmacy and Technology. 2016; 9(1): 69-78. http://dx.doi.org/10.5958/0974-360X.2016.00012.3

5. Keerthi M. Rama Rao N. Santhosh Aruna M. Lakshmi Prasanna J. Solid Dispersions-An Approach to Enhance the Dissolution Rate of Clopidogrel Bisulphate. Asian Journal of Research in Pharmaceutical Sciences. 2014; 4(4): 165-168.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3