Burn Healing Activity of Siam Weed (Chromolaena odorata) leaf Ethanol Extract in Second Degree Burn Wound Induced in Rats

Abstract

Burns are damage to the skin caused by a source of high temperature that can affected skin cells to die. Siam weed (Chromolaena odorata L.), one of the tropical plants belonging to Asteraceae family traditionally can be used to accelerate burn wound healing. The aim of this study was to determine the effect of ethanol extract of Siam weed leaves (Chromolaena odorata L.) on burn healing activity using wound diameter and neutrophil count as parameter values. Twenty fours male white rats (Rattusnovergicus) were divided into 4 treatment groups, namely negative control (C-,burn wound induced,given paracetamol),positive control (C+, burn wound induced, Bioplacentonwas applied to burn wound), 2 treatment group (burn wound induced, P1:Siam weed ethanol extract 5% was applied to burn wound; and P2: Siam weed ethanol extract 10% was applied to burn wound). Second degree burn wound induced in animal back’s using a hot rod.The results of the experiment showed that P2have burn wound healing properties that reduce burn wound diameters and decrease the number of neutrophils. The ethanol extract of Siam weed also possess anti-inflammatory activity and have antioxidant properties that support the ability of burn wound healing.