Preclinical Evaluation of Paederia foetida leaves for Burn Wound Healing Activity

Abstract

The leaves of Paederia foetida are commonly used in folk remedies to treat various types of wounds, especially burn wounds. The present study was carried out to evaluate the effect of hydroalcoholic extract of Paederia foetida on experimentally induced burn wound in rats and compare the effects with known wound healing agents, Silverex ointment and Aloe veragel. An appropriate gel formulation was chosen for topical application in this burn wound model. Animals treated with Paederia foetida leaves extract showed significant reduction in period of epithelialization and wound contraction 50% as compare to control and produced comparable effect as compare to Silverex ointment and Aloe vera gel. From the study It was concluded that Paederia foetida leaves extract applied topically (2.5% and 5% gel formulation) possesses burn wound healing activity.