Formulation and Evaluation of Teneligliptin Nanosuspension

Abstract

In this present study, the drug Teneligliptin is selected for the management of Type-2 Diabetes mellitus. The drug-excipient compatibility study results showed that there is no chemical change occur between the drug and the excipients and there was no functional group change observed. Teneligliptin is poorly water-soluble drug and it was fabricated as nanosuspension of Nine formulations by using nano precipitation technique. In this method, nano size particle size of Teneligliptin was obtained by using different type of various proportions of stabilizers along with other ingredient at different stirring speed. For the prepared formulation (F1-F9) the particle size, polydispersibility index and zeta potential were done. Among nine formulations, formulation 8(F8) results revealed that the values are desirable and stable. The total drug content of all the formulation ranges from 81% to 99%, The average particle size of F1 to F9 batches was found to be in the range of 0.211 nm to 0.486 nm The scanning electron microspore study stated that the nano size particles were spherical in shape. Among all the formulations (F8) was optimized which showed maximum highest percentage of drug release at 24 hours. The cumulative percentage of drug release of formulation 8 (F8) increase with the optimum concentration of stabilizers and tween 80. The release rate of optimized formulation 8(F8) was fitted with various release kinetic studies and the selected formulation followed zero order kinetics. The results of stability study was confirmed that the prepared Teneligliptin nanosuspension is stable during the stability study. Thus, it can be concluded that the nanosuspension method was commercially feasible and cost effective.