Oxidimetric determination of Cetirizine and Levocetirizine in tablets using Oxone

Abstract

This work is aimed at studying the kinetics of Cetirizine (CTZ) and Levocetirizine(L-Cet) oxidation by potassium hydrogen peroxomonosulfate (PMS) in the form of Oxone and developing an analytical method for their quantitative determination. The required amount of CTZ and L-Cet was dissolved in double distilled water, pH buffer solution and PMS solution were added. After 1.5min, the solution was acidified. The excess PMS was iodometrically titrated applying visual end-point detection approach. The reaction was studied in aqueous media at 293 K and over pH range 7.0 to 10.0. The second order rate constants, k (L mol−1 min−1) has been calculated from kinetic data. A suitable scheme has been proposed for the oxidation of CTZ and L-Cet with PMS, which shows electrophilic attack of the monoanion of PMS on a nitrogen atom of the analyzed compounds with the formation of the corresponding amine oxides. CTZ and L-Cet were determined by indirect titration with PMS. The recovery of the assayed analytes in tablets ranged from 99.4 to 101.0%. A paired t-test showed that all results obtained for CTZ and L-Cet in model solutions and dosage form of Levocetirizine (5mg) and Сetirizine (10mg) tablets, using the proposed procedure and the official procedure respectively, were in consonance at the 95 % confidence level, (х ̅ -μ) 100/μ < RSD. Techniques have been developed and the possibility of quantitative determination of Levocetirizine and Cetirizine in substance and tablet forms using Oxone as an analytical reagent has been demonstrated.