Author:
Kobyakov D. S,Bychkova E. Yu,Avdalyan A. M,Bobrov I. P,Lazarev S. A.,Kruglova N. M,Lushnikova E. X,Lazarev A. F,Nepomnyashchikh L. M
Abstract
Topoisomerase IIα (TopoIIα), argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR) and antigen Ki-67 in squamous cell carcinoma of the lung were investigated. Defined Tumors with low and high TopoIIα, Ag-NOR and Ki-67 were defined. TopoIIα had a relationship with clinical and morphological parameters (value T, greatest dimension, stage of disease and tumor differentiation) and proliferation markers (Ag-NOR, Ki-67). Survival of patients with squamous cell carcinoma of the lung with low content of TopoIIα is better as compared with high content of TopoIIα. Survival of patients depends on the mutual content of TopoIIα and clinical and morphological parameters (value N, stage of disease), proliferation markers (Ag-NOR). TopoIIα and Ag-NOR are independent prognostic factors. Mutual research of TopoIIα with clinical and morphological parameters and Ag-NOR has prognostic value in squamous cell carcinoma of the lung.
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