Optical coherence tomography with angiography in the diagnosis of Alzheimer’s disease

Author:

Strumentova Elena S.ORCID,Lobzin Vladimir Y.ORCID,Mal'tsev Dmitriy S.ORCID,Burnasheva Maria A.ORCID,Mosina Maria M.ORCID,Khasanova Almira A.ORCID,Doronina Anna N.ORCID

Abstract

BACKGROUND: Alzheimer’s disease is becoming increasingly common and the number of patients with dementia is steadily increasing. Existing diagnostic methods (neuropsychological testing, cerebrospinal fluid examination, magnetic resonance imaging, and positron emission tomography) are either subjective, inaccessible or invasive and expensive, therefore the search for new methods of Alzheimer’s disease diagnosis is necessary. The retina and the human brain share a common embryonic origin. The use of optical coherence tomography with angiography can help in the diagnosis of the disease, especially at an early stage. AIM: To perform a comparative analysis of the vascular density of the peripapillary region of the human retina with the severity of cognitive impairment and atrophic changes according to MRI in patients with Alzheimer’s disease. MATERIALS AND METHODS: Thirty patients participated in the study: 20 with Alzheimer’s disease and 10 in the control group. All patients underwent collection of complaints and history, general neurological and ophthalmological examination to evaluate inclusion and noninclusion criteria. Subsequently, neuropsychological testing, magnetic resonance imaging of the brain with assessment according to standardized neuroimaging scales, and optical coherence tomography with angiography according to a standard protocol were performed. The results were processed using the Statistica 10 software package (StatSoft, USA). RESULTS: Assessment of retinal microvascular bed condition in Alzheimer’s disease patients revealed a significant level of relative vascular density reduction in the upper half of radial peripapillary plexus of the retina due to reduction of small vessel density (p = 0.02). There was a direct correlation between the severity of the decrease in the FCSRT total score and changes in vascular density in the nasal sector of the retina (r = 0.52). There was a significant inverse relationship between vascular density in the temporal sector and the final GCA score for patients with Alzheimer’s disease (r = 0.57). The Fazekas scale score revealed an inverse correlation between its score and the vascular density in the upper retinal half and its upper sector (r = 0.53). CONCLUSION: Оptical coherence tomography with angiography is a highly informative and promising method for early, including pre-diagnosis of Alzheimer’s disease, which is considerably more accessible and accurate than other techniques.

Publisher

ECO-Vector LLC

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3