Affiliation:
1. E.A. Vagner Perm State Medical University
Abstract
The current literature data on the etiology and pathogenesis of schizophrenia were analyzed. The research method is the analysis of scientific papers on this problem over the past 5 years, presented in the databases of eLibrary, National Library of Medicine and electronic versions of the journals “World Psychiatry Journal”, “The Lancet Psychiatry”, “Schizophrenia Bulletin” and others. Genetic, neurotransmitter, psycho-traumatic, sociocultural and other theories of the origin and development of schizophrenia are analyzed in the review. Schizophrenia is a disease difficult to verify and genetically determined. According to modern theories, the occurrence of schizophrenia and the appearance of symptoms can be influenced by metabolic disorders of neurotransmitters, psycho-traumatic factors, socio-cultural aspects of human life, while the anatomical subcortical structures of the brain are damaged.
Reference25 articles.
1. Пасленова Н.Ю., Холодов А.Ю. Этиология и особенности шизофрении. Инновационно-технологическое развитие науки: сборник статей по итогам международной научно-практической конференции. Стерлитамак 2017; 48–51 / Paslenova N.Yu., Kholodov A.Yu. The etiology and features of schizophrenia. Innovatsionno-tekhnologicheskoe razvitie nauki: sbornik statey po itogam Mezhdunarodnoy nauchno-prakticheskoy konferentsii. Sterlitamak 2017; 48–51 (in Russian).
2. Балабанов А.Г., Борисов Д.А. Генетическая предрасположенность к шизофрении. Авиценна 2022; 100: 19–21 / Balabanov A.G., Borisov D.A. Genetic predisposition to schizophrenia. Avitsenna 2022; 100: 19–21 (in Russian).
3. The genomics of schizophrenia: update and implications
4. Mah S., Nelson M.R., Delisi L.E., Reneland R.H., Markward N., James M.R., Nyholt D.R., Hayward N., Handoko H., Mowry B., Kammerer S., Braun A. Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia. Mol. Psychiatry. 2006; 11 (5): 471–478.
5. Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort