Prospective 5-year follow-up of patients with acute coronary syndrome and percutaneous coronary intervention

Author:

Musikhina Natalia A.ORCID,Teploukhova Alina I.ORCID,Petelina Tatyana I.ORCID,Gorbatenko Elena A.ORCID,Bessonov Ivan S.ORCID,Gapon Lyudmila I.ORCID

Abstract

Background. The study of predictors that negatively affect the long-term prognosis of patients with an increased risk of coronary syndrome can improve the effectiveness of measures for the secondary prevention of cardiovascular events. Aim. To determine the factors that have a negative impact on 5-year survival in patients with acute coronary syndrome and percutaneous coronary intervention. Material and methods. 135 patients with acute coronary syndrome enrolled in the Register of percutaneous coronary interventions in 20122013 at the Tyumen Cardiology Center, a branch of the Tomsk Research Institute of Cardiology of the Russian Academy of Sciences, were included in the study. After 12 and 60 months, the clinical status of patients and ongoing drug therapy were evaluated, and an examination including echocardiography with an ultrasound scanner, daily monitoring of the electrocardiogram and standard blood pressure measuring was performed. Laboratory studies included general and biochemical blood tests. To calculate the factors associated with poor prognosis, a Cox proportional hazards regression model with stepwise inclusion was used. Survival was assessed by the KaplanMeier method using the Log-rank test (logarithmic test). Results. After 1 year, only three-quarters of patients continued the recommended drug therapy, a similar trend continued after 5 years of follow-up. The number of patients without any antiplatelet therapy increased from 19.9% after 12 months to 29.7% after 60 months. Overall survival after 1 year was 97.1%, after 5 years 86.7%. The risk of death increased in the presence of chronic kidney disease (risk ratio 15.1; 95% confidence interval 4.3052.93; p=0.001); type 2 diabetes mellitus (risk ratio 3.67; 95% confidence interval 1.1811.43; p=0.025), history of stroke (risk ratio 9.07; 95% confidence interval 1.8544.60; p=0.007), in patients with a heart rate 80 beats per minute [risk ratio 4.3; (95% confidence interval 1.5112.26; p=0.006) and at pulse pressure 60 mm Hg (risk ratio 4.68; 95% confidence interval 1.6013.72; p=0.005)]. Conclusion. The predictors that influenced the 5-year survival of patients after acute coronary syndrome and percutaneous coronary intervention were chronic kidney disease, diabetes mellitus, a history of stroke, high pulse pressure, and increased heart rate of more than 80 beats per minute.

Publisher

ECO-Vector LLC

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3