Affiliation:
1. I.M. Sechenov First Moscow State Medical University (Sechenov University)
2. I.M. Sechenov First Moscow State Medical University
3. I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
4. Первый московский государственный медицинский университет им И. М. Сеченова (Сеченовский университет)
Abstract
Bullous scleroderma is a rare variant of localized scleroderma characterized by the formation of subepidermal tense blisters. At the moment, the etiology and pathogenesis of dermatosis is not fully understood, but a number of authors consider the pathology of the endocrine system as a trigger for the development of localized and systemic scleroderma.
Untimely or erroneous diagnosis of bullous scleroderma leads to the risk of developing a systemic process, irreversible cosmetic defects and even disability. We present a clinical observation of widespread bullous scleroderma in a patient that developed against the background of pituitary macroadenoma, panhypopituitarism, secondary hypothyroidism, adrenal insufficiency, hypogonadism and secondary amenorrhea.