Tsitogeneticheskie izmeneniya v limfotsitakh perifericheskoy krovi v otsenke effektivnosti lecheniya bol'nykh s osteogennoy sarkomoy

Abstract

The baseline cytogenetic examination of patients with osteogenic sarcoma (OS) revealed specific and nonspecific chromosomal aberrations that involved the count of hypo-, hyperaneuploid, and polyploid cells with small double chromosomes, unstable chromosomal anomalies. The efficiency of treatment of patients with OS was comparatively evaluated in relation to the type of therapy and the baseline level of chromosomal anomalies. The therapeutic effect may be predicted from the total count of cells with chromosomal aberrations.