Effects of Statin Therapy on Plasma Proprotein Convertase Subtilisin/kexin Type 9 and Sortilin Levels in Statin-Naive Patients with Coronary Artery Disease
Author:
Affiliation:
1. Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital
2. Department of Advanced Medical Technology and Development, BML, Inc.
Publisher
Japan Atherosclerosis Society
Subject
Biochemistry, medical,Cardiology and Cardiovascular Medicine,Internal Medicine
Link
https://www.jstage.jst.go.jp/article/jat/23/7/23_33407/_pdf
Reference39 articles.
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2. 2) Seidah NG, Khatib AM, Prat A. The proprotein convertases and their implication in sterol and/or lipid metabolism. Biol Chem, 2006; 387: 871-877
3. 3) Lambert G, Krempf M, Costet P. PCSK9: a promising therapeutic target for dyslipidemias? Trends Endocrinol Metab, 2006; 17: 79-81
4. 4) Graham MJ, Lemonidis KM, Whipple CP, Subramaniam A, Monia BP, Crooke ST, Crooke RM. Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice. J Lipid Res, 2007; 48: 763-767
5. 5) Lagace TA, Curtis DE, Garuti R, McNutt MC, Park SW, Prather HB, Anderson NN, Ho YK, Hammer RE, Horton JD. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest, 2006; 116: 2995-3005
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