Affiliation:
1. Saint Petersburg Institute of Bioregulation and Gerontology
2. City Polyclinic of the City of Belgorod, Belgorod
3. Research Medical Centre «GERONTOLOGY», Moscow
4. esearch Medical Centre «GERONTOLOGY», Moscow , Clinic of aesthetic medicine DEGA, Saint-Petersburg
Abstract
Aging is a process affecting various organ and tissue systems. The development of age-related changes occurs at the molecular, genetic, cellular, organ and organizational levels. At the population level, accelerated aging can manifest itself as an unfavorable upward dynamics of the incidence of age-associated diseases, an early manifestation of pathology. Рurpose. To study the features of the cellular composition of the blood depending on the sequence of manifestation of a number of diseases. Materials and methods. Statistical collections for 2015–2019 acted as materials, clinical blood test (cellular composition of blood) of 17 957 patients hospitalized in Saint-Petersburg City Hospital No 2 from 01.01.2015 to 31.12.2019 with the following diagnoses (ICD-10 codes) is also analyzed: E05, E10, E11, G20, H25, H40, I10, I10–I15, I20, M80–M81, N20–N23. Results. The analysis established a significant correlation with the priority of disease manifestation for only two indicators: lymphocyte count (r=-0.675; p=0.022) and red blood cells (r=-0.639; p=0.033). Correlation analysis demonstrated a significant association between age-specific incidence index (ASII) and absolute lymphocyte and erythrocyte counts. The sequence of manifestation of the considered diseases, compiled on the basis of ASII ranking, is closely related to the age characteristics of the cellular composition of the blood. Conclusion. Thus, features of the cellular composition of the blood were found depending on the manifestation of diseases. The identified patterns corresponding to age-related changes will allow the development of new approaches in the study of the pathophysiological gerontological continuum.
Publisher
Russian Vrach, Publishing House Ltd.
Reference23 articles.
1. Khavinson V., Linkova N., Dyatlova A. et al. Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation. Cells. 2023; 1: 106. DOI: 10.3390/cells12010106
2. Голубев А.Г. Биология продолжительности жизни и старения. СПб: Издательство «Н-Л», 2009; 288 c. [Golubev A.G. Biology of life expectancy and aging. SPb: Izdatelstvo «N-L», 2009; 288 p. (in Russ.)].
3. Bousquet J., Kuh D. Operational definition of active and healthy ageing (AHA): a conceptual framework. J Nutr Health Aging. 2015; 19 (9): 955–60. DOI: 10.1007/s12603-015-0589-6
4. Гаврилов И.В., Мещанинов В.Н., Щербаков Д.Л. и др. Скрининг функциональных, биохимических и клеточно-гематологических показателей организма как маркеров процесса старения человека. Вестник уральской медицинской академической науки. 2018; 15 (5): 691–703 [Gavrilov I.V., Meshchaninov V.N., Shcherbakov D.L. et al. Screening of functional, biochemical and cellular hematologic parameters of the human organism as markers of the process of human aging. Journal of Ural Medical Academic Science. 2018; 15 (5): 691–703 (in Russ.)]. DOI: 10.22138/2500-0918-2018-15-5-691-703
5. Rybtsova N., Berezina T., Kagansky A. et al. Can blood-circulating factors unveil and delay your biological aging? Biomedicines. 2020; 8: 1–31. DOI 10.3390/biomedicines8120615