Affiliation:
1. ANKARA ÜNİVERSİTESİ, ANKARA VETERİNER FAKÜLTESİ
2. KIRIKKALE UNIVERSITY
Abstract
In N-methyl-N-nitrosourea (MNU)-induced colon cancer modeling in rats, it was aimed to evaluate the regressive effect of grayanotoxin-rich Turkish mad honey and 5-fluorouracil (5-FU), separately and together. Study groups were control group (CG), cancer control group (CCG), 5-Flourouracil group (FUG), Turkish mad honey group (HG), Turkish mad honey and 5-FU combined group (FU-HG). WBC, lymphocyte, eosinophil, basophil, serum LDH, TOS, and total protein values determined in the rats in the CCG were significantly lower than the values determined in the rats in CG, and serum Bcl-2 and survivin levels were significantly higher. The presence of anaplastic epithelial cells, vascularization, precancerous changes, and inflammatory infiltration detected in the colon and small intestine of the rats in FU-HG, FUG, HG were less intense (p
Publisher
Veterinary Journal of Ankara University
Subject
General Veterinary,Animal Science and Zoology
Reference28 articles.
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