Antioxidant, Anti-inflammatory, and Anti-wrinkle Effects of Sargassum horneri Extract in vitro

Author:

Kim Dong-Sub,Kim Geon,Sung Nak-Yun,Han In-Jun,Kim Minjee,Kim Chun Sung,Jung Yunu

Abstract

Purpose: This study mainly aimed to confirm the antioxidant activity, antiinflammatory, and collagen production enhancement effects of the <i>Sargassum horneri</i> (SH) extract.Methods: The measurement of the total flavonoid and total polyphenol content, 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities confirmed the antioxidant efficacy of the SH extract. The expression level of interleukin 6 (IL-6) and its upstream mechanism pathway, mitogen-activated protein kinases (MAPK), were evaluated for anti-inflammatory efficacy in human dermal fibroblast (HDF) cells. The collagenase and elastase levels were measured in terms of the ability to inhibit collagen degradation. On the contrary, collagen type 1 (COL1) and matrix metallopeptidase 1 (MMP1) were conducted to confirm the collagen production ability.Results: The DPPH and ABTS radical scavenging abilities of the SH extract were 86.87%±12% and 76.49%±2.94%, respectively, at the highest concentration of 1000 μg/mL, confirming 51.62±1.945 and 79.65±4.732 mg/g of total polyphenol and total flavonoid, respectively, which are known to have antioxidant effects. The anti-inflammatory effect of SH in HDF cells was reduced by up to 56.8% compared to the control group due to a significant decrease in MAPK. The SH extract significantly reduced collagenase and elastase, thereby inhibiting collagen degradation. On the contrary, increasing COL1 and decreasing MMP1 in HDF cells confirmed collagen production.Conclusion: Therefore, SH extract is a potential functional cosmetic through its antioxidant, anti-inflammatory, and collagen degradation inhibitory activities.

Funder

Ministry of Oceans and Fisheries

Korea Institute of Marine Science and Technology promotion

Publisher

Korea Institute for Skin and Clinical Sciences

Subject

General Engineering,Ocean Engineering

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