The Role of Cytochrome 2B1 Substrate Recognition Site Residues 115, 294, 297, 298, and 362 in the Oxidation of Steroids and 7-Alkoxycoumarins
Author:
Publisher
Elsevier BV
Subject
Molecular Biology,Biochemistry,Biophysics
Reference47 articles.
1. Interactions of hepatic cytochromes P-450 with steroid hormones
2. Molecular basis for a functionally unique cytochrome P450IIB1 variant.
3. Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1
4. Engineering of cytochrome P450 2B1 specificity. Conversion of an androgen 16 beta-hydroxylase to a 15 alpha-hydroxylase.
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2. Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes;Xenobiotica;2022-07-03
3. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations;Biochemistry;2016-03-24
4. A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States;Journal of Pharmacology and Experimental Therapeutics;2013-04-30
5. X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: Insights into compensatory rearrangements of the binding pocket;Archives of Biochemistry and Biophysics;2013-02
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