The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements

Author:

Fukiwake Tomohide1,Yamazaki Midori1,Takahashi Kazunaga1,Doi Takahiro2,Kawaguchi Masami2,Enomoto Keigo1,Yoshino Hiroki1,Uchimoto Katsuya1,Nishimura Maki1

Affiliation:

1. Chiba Prefectural Institute of Public Health

2. Osaka Institute of Public Health

Publisher

Japanese Society for Food Hygiene and Safety

Subject

General Medicine

Reference7 articles.

1. 1) Doi, T., Takahashi, K., Yamazaki, M., Asada, A.,Takeda, A., Kiyota, K., Tagami, T., Sawabe, Y., Yamano, T. Characterization of a new illicit phosphodiesterase-type-5 inhibitor identified in the softgel shell of a dietary supplement. Journal of Pharmaceutical and Biomedical Analysis, 161, 61–65 (2018).

2. 2) 日本イーライリリー株式会社「勃起不全治療剤シアリス錠 添付文書」2018年8月改定第10版

3. 3) Fukiwake, T., Hasegawa, T., Ashizawa, E., Ogura, M., Takahashi, K., Saijo, M., Motoki, Y. Screening analysis of pharmaceutical agents in dietary supplements using UPLC/PDA. Chibaken Eiseikenkyusyo Nenpo (Annual Report of Chiba Prefectural Institute of Public Health), 59, 79–83 (2010).

4. 4) Kurita, H., Mizuno, K., Kuromi, K., Suzuki, N., Ueno, C., Kamimura, M., Fujiwara, A., Owada, K., Ogo, N., Yamamoto, M. Identification of aminotadalafil and its stereoisomers contained in health foods using chiral liquid chromatography-mass spectrometry. Journal of Health Science, 54(3), 310–314 (2008).

5. 5) Patent WO 1995019978 A1「四環式誘導体,製造方法および用途」1997年8月19日公表

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