Affiliation:
1. A.I. Evdokimov Moscow State Medical University of Medicine and
Dentistry
Abstract
Optical coherence tomography (OCT) is widely used in ophthalmological practice. The review presents the results of OCT in patients with somatotropin-producing pituitary adenoma, or somatotropinoma, which is a hormone-active tumor of the adenohypophysis, characterized by excessive production of somatotropic hormone (STH). It stimulates the secretion of type I insulin-like growth factor (IGF-I). The mechanisms of STH action (pro-angiogenic action, stimulation endothelial cell proliferation and migration, development of endothelial dysfunction and retinal edema) requires much attention to the results of examination of patients with somatotropinomas using modern diagnostic methods, such as OCT.
Reference42 articles.
1. Dudina M.A., Dogadin S.A., Lobyntseva L.A., Gayduk K.K., Borovik O.V.Concentration of somatotropin and insulin-like growth factor-1 in blood, relation with pituitary somatotropinoma size in patients with acromegaly. Siberian medical review. 2012; 73 (1): 15–8 (in Russian)].
2. Tjörnstrand A., Gunnarsson K., Evert M., et al.The incidence rate of pituitary adenomas in western Sweden for the period 2001-2011. Eur. J. Endocrinol. 2014; 171 (4): 519–26. doi: 10.1530/eje-14-0144
3. Mehta G.U., Lonser R.R. Management of hormone-secreting pituitary adenomas. Neuro Oncol. 2017; 19 (6): 762–73. doi:10.1093/neuonc/now130
4. Agustsson T.T., Baldvinsdottir T., Jonasson J.G., et al. The epidemiology of pituitary adenomas in Iceland, 1955–2012: a nationwide population-based study. Eur. J. Endocrinol. 2015; 173 (5): 655–64. doi:10.1530/eje-15-0189
5. Vorotnikova S.Yu., Pigarova E.A., Dzeranova L.K. Metabolic effects of growth hormone. Obesity and metabolism. 2012; 73 (1): 15–8 (in Russian). doi: 10.14341/2071-8713-5308