Mature Adipocyte-Derived Dedifferentiated Fat Cells Can Trans-Differentiate into Osteoblasts In Vitro and In Vivo only by All-Trans Retinoic Acid

Author:

Oki Yoshinao1,Watanabe Saiko1,Endo Tuyoshi1,Kano Koichiro1

Affiliation:

1. Laboratory of Cell and Tissue Biology, Graduate School of Bioresource Sciences, Nihon University

Publisher

Japan Society for Cell Biology

Subject

Cell Biology,Molecular Biology,Physiology,General Medicine

Reference66 articles.

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2. Centrella, M., Casinghino, S., Kim, J., Pham, T., Rosen, V., Wozney, J., and McCarthy, T.L. 1995. Independent changes in type I and type II receptors for transforming growth factor beta induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype. Mol. Cell. Biol., 15: 3273–3281.

3. Chen, D., Chen, H., Feng, J.Q., Windle, J.J., Koop, B.A., Harris, M.A., Bonewald, L.F., Boyce, B.F., Wozney, J.M., Mundy, G.R., and Harris, S.E. 1995. Osteoblast cell lines derived from a transgenic mouse containing the osteocalcin promoter driving SV40 T-antigen. Mol. Cell. Differ., 3: 193–212.

4. Dalei, S. and Lazar, M.A. 1997. Peroxisome proliferators activated receptor γ, CCAAT/enhancer-binding protein α, and cell cycle status regulate the commitment to adipocyte differentiation. J. Biol. Chem., 272: 21473–21478.

5. de Crombrugghe, B., Lefebvre, V., Behringer, R.R., Bi, W., Murakami, S., and Huang, W. 2000. Transcriptional mechanisms of chondrocyte differentiation. Matrix Biol., 19: 389–394.

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