Towards Enhancing Therapeutic Glycoprotein Bioproduction: Interventions in the PI3K/AKT/mTOR Pathway

Author:

Mahameed Mohamed1,Sulieman Afnan1,Alkam Duah2,Tirosh Boaz1

Affiliation:

1. Institute for Drug Research, The Hebrew University of Jerusalem

2. Department of Biomedical Informatics, University of Arkansas for Medical Sciences

Publisher

Japan Society for Cell Biology

Subject

Cell Biology,Molecular Biology,Physiology,General Medicine

Reference68 articles.

1. Adli, M. 2018. The CRISPR tool kit for genome editing and beyond. Nat. Commun., 9: 1911.

2. Ashwell, G. and Harford, J. 1982. Carbohydrate-specific receptors of the liver. Annu. Rev. Biochem., 51: 531–554.

3. Barnes, L.M., Bentley, C.M., and Dickson, A.J. 2000. Advances in animal cell recombinant protein production: GS-NS0 expression system. Cytotechnology, 32: 109–123.

4. Ben-Sahra, I., Howell, J.J., Asara, J.M., and Manning, B.D. 2013. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science, 339: 1323–1328.

5. Ben-Sahra, I., Hoxhaj, G., Ricoult, S.J.H., Asara, J.M., and Manning, B.D. 2016. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science, 351: 728–733.

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